Contract Projects

Competitive advantages of Neuro-Zone can be summarized in the following main categories:

SCIENTIFIC EXPERTISE: we have a very talented group of post-doc level international recognized scientists in the lab, with strong research background in several areas (cancer, neurodegenerative diseases, autoimmune diseases, cardiovascular, skin and ophthalmic diseases), from in vitro cellular work, to in vivo animal work, to gene/genomic analysis.

SCIENTIFIC INTERACTION: we support scientists in research centers, biotechs or pharmas in experimental layout, physically run experiments in-house and carry out data analysis and interpretation.

SCIENTIFIC COLLABORATION: we participate in international networks and research efforts to dissect cell-cell crosstalk in complex inflammatory contexts.

Our Scientific Publications

a list of recent projects in which Neuro-Zone has acted as partner

  • Maffey A, Storini C, Diceglie C, Martelli C, Sironi L, Calzarossa C, Tonna N, Lovchik R, Delamarche E, Ottobrini L, Bianco F. Mesenchymal stem cells from tumor microenvironment favour breast cancer stem cell proliferation, cancerogenic and metastatic potential, via ionotropic purinergic signalling. Scientific Reports 10/2017; 7(1):13162
  • Crotta K, Casnici C, Tonna N, Lattuada D, Bianco F, Marelli O. Characterization of a Monoclonal Antibody Specific for the Growth Hormone Secretagogue Receptor. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy 04/2017; 36(2):37-43

  • Vercelli A, Biggi S, Sclip A, Repetto IE, Cimini S, Falleroni F, Tomasi S, Monti R, Tonna N, Morelli F, Grande V, Stravalaci M, Biasini E, Marin O, Bianco F, di Marino D, Borsello T. Exploring the role of MKK7 in excitotoxicity and cerebral ischemia: a novel pharmacological strategy against brain injury. Cell Death & Disease 08/2015; 6:e1854

  • Casnici C, Lattuada D, Tonna N, Crotta K, Storini C, Bianco F, Truzzi M, Corradini C, Marelli O. Optimized “in vitro” culture conditions for human rheumatoid arthritis synovial fibroblasts. Mediators of Inflammation 2014
  • Tonna N, Bianco F, Matteoli M, Cagnoli C, Antonucci A, Manfredi A, Mauro N, Ranucci E, Ferruti P. A soluble biocompatible guanidine-containing polyamidoamine as promoter of primary brain cell adhesion and in vitro cell culturing. Science and Technology of Advanced Materials 08/2014; 15(4):045007

  • EU Funded Projects SHOCKOMICS – Multiscale approach to the identification of molecular biomakers in acute heart failure induced by shock.
  • Delamarche E, Tonna N, Lovchik R, Bianco F, Matteoli M. Pharmacology on microfluidics: multimodal analysis for studying cell-cell interaction. Current Opinion in Pharmacology 2013 Oct;13(5):821-8
  • Tunesi M, Bossio K, Tonna N, Bianco F, Giordano C, Chiesa R. Mesenchymal stem cell differentiation on electrochemically –modified titanium substrates: an optimized approach for biomedical applications. J Appl Biomater Funct Mater 2013; 11 (1): 9-17
  • Lattuada D, Crotta K, Tonna N, Casnici C, Benfante R, Fornasari D, Bianco F, Longhi R, Marelli O. The expression of GHS-R in primary neurons is dependent upon maturation stage and regional localization. PLOS ONE (2013), Jun 5;8(6):e64183
  • Bossio C, Mastrangelo R, Morini R., Tonna N, Coco S, Verderio C, Matteoli M, Bianco F. A simple method to generate adipose stem cell-derived neurons for screening purposes. Journal of Molecular Neuroscience 2013, Mar 7

  • Bianco F, Tonna N, Lovchik RD, Mastrangelo R, Morini R, Ruiz A, Delamarche E, Matteoli M. Overflow microfluidic networks: application to the biochemical analysis of brain cell interactions in complex neuroinflammatory scenarios. Anal Chem. 2012 Oct 24.
  • Parolini D, Cassinelli L, Razini P, Sitzia C, Tonna N, Erratico S, Colleoni F, Angeloni V, Maffioli E, Farini A, Maciotta S, Porretti L, Belicchi M, Bianco F, Tedeschi G, Meregalli M, Torrente Y. Expression of CD20 reveals a new store –operated calcium entry modulator in skeletal muscle. The International Journal of Biochemistry & Cell Biology. 2012: 44; 2095– 2105
  • Turola E, Furlan R, Bianco F, Matteoli M, Verderio C. Microglial microvesicle secretion and intercellular signaling. PLOS ONE (2013), Jun 5;8(6):e64183
  • Bossio C, Mastrangelo R., Morini R., Tonna N, Coco S, Verderio C, Matteoli M, Bianco F. A simple method to generate adipose stem cell-derived neurons for screening purposes. Front Physiol. 2012; 3:149

  • Perale G, Giordano C, Bianco F, Rossi F, Tunesi M, Daniele F, Crivelli F, Matteoli M, Masi M. Hydrogel for cell housing in the brain and in the spinal cord. Int J Artif Organs. 2011 Mar;34(3):295-303.

  • Lovchik RD, Bianco F, Tonna N, Ruiz A, Matteoli M, Delamarche E. Overflow microfluidic networks for open and closed cell cultures on chip. Anal Chem. 2010 May 1;82(9):3936-42
  • Lovchik RD, Tonna N., Bianco F., Matteoli M., Delamarche E. A microfluidic device for depositing and addressing two cell populations with intercellular population communication capability. Biomed Microdevices. 2010 Apr;12(2):275-82

  • Stefano L, Racchetti G, Bianco F, Passini N, Gupta RS, Bordignon PP, Meldolesi J. The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor. J Neurochem. 2009 Jul;110(1):284-94
  • Lovchick RD, Bianco F, Matteoli M, Delamarche E. Controlled deposition of cells in sealed microfluidics using flow velocity boundaries. Lab on Chip. 2009 May 21;9(10):1395-402.
  • Bianco F, Perrotta C, Novellino L, Francolini M, Riganti L, Menna E, Saglietti L, Schuchman E, Furlan R, Clementi E., Matteoli M, Verderio C. Acid sphingomyelinase activity triggers microparticle release from glial cell. EMBO J. 2009 Apr 22;28(8):1043-54